Enhancer-Promoter Visualization

Region Start

Region End

Filter Samples

Mononuclear Phagocytes (38/38)

THP1_LPS_4hr-Engreitz

THP_pmaLPS_ATAC_6h

CD14-positive_monocyte_treated_with_LPS_4h-Novakovic2016

CD14-positive_monocyte_treated_with_BG_1h-Novakovic2016

CD14-positive_monocyte_treated_with_RPMI_d6-Novakovic2016

THP1-Engreitz

THP_pmaLPS_ATAC_96h

CD14-positive_monocyte_treated_with_BG_d1-Novakovic2016

THP_pmaLPS_ATAC_72h

THP-1_monocyte-VanBortle2017

CD14-positive_monocyte_treated_with_LPS_d1-Novakovic2016

CD14-positive_monocyte-ENCODE

THP_pmaLPS_ATAC_2h

dendritic_cell_treated_with_Lipopolysaccharide_0_ng-mL_for_0_hour-Garber2017

CD14-positive_monocyte_treated_with_RPMI_1h-Novakovic2016

U937_LPS_4hr-Engreitz

CD14-positive_monocyte-Novakovic2016

dendritic_cell_treated_with_Lipopolysaccharide_100_ng-mL_for_6_hour-Garber2017

CD14-positive_monocyte_treated_with_BG_4h-Novakovic2016

THP_pmaLPS_ATAC_0h

HAP1

THP-1_macrophage-VanBortle2017

dendritic_cell_treated_with_Lipopolysaccharide_100_ng-mL_for_1_hour-Garber2017

U937-Engreitz

CD14-positive_monocyte_treated_with_RPMI_d1-Novakovic2016

CD14-positive_monocyte_treated_with_RPMI_4h-Novakovic2016

CD14-positive_monocyte_treated_with_LPS_d6-Novakovic2016

CD14-positive_monocyte_treated_with_LPS_1h-Novakovic2016

THP_pmaLPS_ATAC_24h

THP_pmaLPS_ATAC_1h

dendritic_cell_treated_with_Lipopolysaccharide_100_ng-mL_for_2_hour-Garber2017

CD14-positive_monocyte_treated_with_BG_d6-Novakovic2016

dendritic_cell_treated_with_Lipopolysaccharide_100_ng-mL_for_30_minute-Garber2017

THP_pmaLPS_ATAC_120h

dendritic_cell_treated_with_Lipopolysaccharide_100_ng-mL_for_4_hour-Garber2017

THP_pmaLPS_ATAC_48h

CD14-positive_monocytes-Roadmap

THP_pmaLPS_ATAC_12h

B Cells (9/9)

Karpas-422-ENCODE

BJAB-Engreitz

BJAB_anti-IgM_anti-CD40_4hr-Engreitz

B_cell-ENCODE

OCI-LY7-ENCODE

GM12878-Roadmap

MM.1S-ENCODE

CD19-positive_B_cell-Roadmap

CD8-positive_alpha-beta_T_cell-ENCODE

T Cells (8/8)

Jurkat_anti-CD3_PMA_4hr-Engreitz

Jurkat-Engreitz

CD3-positive_T_cell-Roadmap

CD4-positive_helper_T_cell-ENCODE

CD8-positive_alpha-beta_T_cell-Corces2016

thymus_fetal-Roadmap

CD4-positive_helper_T_cell-Corces2016

T-cell-ENCODE

Other haematopoietic cells (8/8)

spleen-ENCODE

K562-Roadmap

CD56-positive_natural_killer_cells-Roadmap

erythroblast-Corces2016

CD34-positive_mobilized-Roadmap

megakaryocyte-erythroid_progenitor-Corces2016

natural_killer_cell-Corces2016

IMR90-Roadmap

Fibroblasts (5/5)

foreskin_fibroblast-Roadmap

fibroblast_of_dermis-Roadmap

fibroblast_of_arm-ENCODE

astrocyte-ENCODE

fibroblast_of_lung-Roadmap

Epithelial (42/42)

small_intestine_fetal-Roadmap

epithelial_cell_of_prostate-ENCODE

HCT116-ENCODE

MCF-7-ENCODE

adrenal_gland_fetal-ENCODE

H7

keratinocyte-Roadmap

MCF10A-Ji2017

pancreas-Roadmap

mammary_epithelial_cell-Roadmap

stomach-Roadmap

LoVo

A549_treated_with_ethanol_0.02_percent_for_1_hour-Roadmap

PC-9-ENCODE

H1-hESC-Roadmap

thyroid_gland-ENCODE

HT29

MDA-MB-231

iPS_DF_19.11_Cell_Line-Roadmap

large_intestine_fetal-Roadmap

Panc1-ENCODE

adrenal_gland-ENCODE

MCF10A_treated_with_TAM24hr-Ji2017

trophoblast_cell-ENCODE

H1_BMP4_Derived_Trophoblast_Cultured_Cells-Roadmap

uterus-ENCODE

body_of_pancreas-ENCODE

stomach_fetal-Roadmap

H9-Roadmap

transverse_colon-ENCODE

H1_BMP4_Derived_Mesendoderm_Cultured_Cells-Roadmap

breast_epithelium-ENCODE

induced_pluripotent_stem_cell-ENCODE

LNCAP

H1_Derived_Mesenchymal_Stem_Cells-Roadmap

ovary-Roadmap

sigmoid_colon-ENCODE

skeletal_muscle_myoblast-Roadmap

bipolar_neuron_from_iPSC-ENCODE

coronary_artery_smooth_muscle_cell-Miller2016

SK-N-SH-ENCODE

muscle_of_trunk_fetal-Roadmap

Other (23/23)

adipose_tissue-ENCODE

HeLa-S3-Roadmap

hepatocyte-ENCODE

heart_ventricle-ENCODE

spinal_cord_fetal-ENCODE

coronary_artery-ENCODE

HepG2-Roadmap

muscle_of_leg_fetal-Roadmap

gastrocnemius_medialis-ENCODE

brite_adipose-Loft2014

placenta-Roadmap

liver-ENCODE

A673-ENCODE

white_adipose-Loft2014

cardiac_muscle_cell-ENCODE

osteoblast-ENCODE

H1_Derived_Neuronal_Progenitor_Cultured_Cells-Roadmap

endothelial_cell_of_umbilical_vein-Roadmap

NCCIT

myotube_originated_from_skeletal_muscle_myoblast-Roadmap

psoas_muscle-Roadmap

endothelial_cell_of_umbilical_vein_vegf_stim_4_hours-zhang2013

endothelial_cell_of_umbilical_vein_vegf_stim_12_hours-zhang2013

Enhancer Regions:

■ Enhancers containing rs1250566

■ All other predicted enhancers

This plot is interactive!

Enhancer-Gene Connections:

■■■Max. ABC score of enhancer-gene connections overlapping by sample groups across up/downstream genes.

DNA Accessibility:

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238 Kbp

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ABC
Enhancer-Gene
Connections

This web application visualizes genome-wide enhancer-gene connections predicted with the Activity-By-Contact (ABC) model. You can interactively browse the entire human genome (hg19), filter enhancers by region, gene, or sample, and link enhancers to genetic risk variants.

For more background information please refer to our publication: Nasser et al., Genome-wide enhancer maps link risk variants to disease genes, Nature (2021).

For more information about the visualizations, please click on Show Introduction. If you find a bug or have ideas for improvements, please don't hesitate open an issue on GitHub or ping @flekschas.